Molecularly imprinted polymers (MIPs) have been utilized as recognition elements for a wide range of analytes due to their high stability and remarkable mechanical properties. However, the traditional MIPs suffered some limitations for the practical applications. To broaden the application scope, multifunctional core-shell MIPs (CS-MIPs) have attracted increasing attentions in various fields such as separation, sensing and imaging. This review mainly discusses the recent developments of CS-MIPs with a non-imprinted core (Core@MIP particles) and CS-MIPs with a non-imprinted shell (MIP@Shell particles). In addition, other novel miscellaneous CS-MIPs with a hollow-core, a semi-shell, or an empty-shell are summarized. The challenges and prospects of the CS-MIPs are also presented to identify research gaps and prospective trends in design and applications of multifunctional CS-MIPs in analytical science.

中文翻译：

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核壳分子印迹颗粒

分子印迹聚合物（MIP）的高稳定性和出色的机械性能已被用作各种分析物的识别元件。但是，传统的MIP在实际应用中存在一些局限性。为了扩大应用范围，多功能核壳MIP（CS-MIP）在分离，传感和成像等各个领域引起了越来越多的关注。这篇评论主要讨论具有非压印核心（Core @ MIP粒子）的CS-MIP和具有非压印外壳（MIP @ Shell粒子）的CS-MIP的最新发展。另外，总结了具有空心，半壳或空壳的其他新颖的杂项CS-MIP。