Biomolecular receptors are able to process information by responding differentially to combinations of chemical signals. Synthetic receptors that are likewise capable of multi-stimuli response can form the basis of programmable molecular systems, wherein specific input sequences create distinct outputs. Here we report a pseudo-cuboctahedral assembly capable of cooperatively binding anionic and neutral guest species. The binding of pairs of fullerene guests was observed to effect the all-or-nothing cooperative templation of an S₆-symmetric host stereoisomer. This bis-fullerene adduct exhibits different cooperativity in binding pairs of anions from the fullerene-free parent: in one case, positive cooperativity is observed, while in another all binding affinities are enhanced by an order of magnitude, and in a third the binding events are only minimally perturbed. This intricate modulation of binding affinity, and thus cooperativity, renders our new cuboctahedral receptor attractive for incorporation into systems with complex, programmable responses to different sets of stimuli.

中文翻译：

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立体化学可塑性调节CoII12L6八面体中的协同结合

生物分子受体能够通过对化学信号的组合做出不同的反应来处理信息。同样具有多重刺激反应能力的合成受体可以构成可编程分子系统的基础，其中特定的输入序列会产生不同的输出。在这里，我们报告伪铜八面体大会能够合作结合阴离子和中性的客体物种。观察到富勒烯客人对的结合影响了S ₆的全有或无合作模板。对称的主体立体异构体。这种双富勒烯加合物在与来自富勒烯的母体的阴离子结合对中表现出不同的协同作用：在一种情况下，观察到正协同作用，而在另一种情况下，所有结合亲和力均提高一个数量级，在第三种结合事件中只被最小程度地扰动了。这种对结合亲和力的复杂调节，从而使协同作用，使我们的新型八面体受体具有吸引力，可将其掺入对不同组刺激具有复杂可编程响应的系统中。