The antimicrobial activity of bitespiramycin (BT) against Chlamydia trachomatis (Ct), Chlamydia pneumoniae (Cp), Ureaplasma urealyticum (Uu), and Mycoplasma pneumoniae (Mp), was compared with those of azithromycin (AZM) and acetylspiramycin (AT-SP) in vitro. Furthermore, the anti-Mp activities of BT and AZM were evaluated in a hamster model. The activities of BT in vitro were similar to those of AZM but were more effective than those of AT-SP. BT effectively inhibited Mp infection at a dose of 200 mg/kg in a hamster model.

中文翻译：

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新型基因工程大环内酯类比螺旋霉素的抗菌活性

将比特螺旋霉素（BT）对沙眼衣原体（Ct），肺炎衣原体（Cp），解脲脲原体（Uu）和肺炎支原体（Mp）的抗菌活性与阿奇霉素（AZM）和乙酰螺旋霉素（AT-SP）的抗菌活性进行了比较体外。此外，在仓鼠模型中评估了BT和AZM的抗Mp活性。BT的体外活性与AZM相似，但比AT-SP更有效。在仓鼠模型中，BT以200 mg / kg的剂量有效抑制Mp感染。