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Persistent luminescent particles containing bioactive glasses: Prospect toward tracking in-vivo implant mineralization using biophotonic ceramics
Journal of the European Ceramic Society ( IF 5.8 ) Pub Date : 2017-08-24 , DOI: 10.1016/j.jeurceramsoc.2017.08.024
M. Saarinen , A. Nommeots-Nomm , M. Hokka , J. Laurila , I. Norrbo , M. Lastusaari , J. Massera , L. Petit

In this paper, we demonstrate that persistent luminescent bodies can be obtained by carefully choosing the sintering temperatures and duration. A borosilicate and a phosphate glasses were sintered into bodies with persistent luminescent (PeL) SrAl2O4:Eu2+,Dy3+ microparticles which have a green emission up to tens of hours after ceasing irradiation. When sintered at high temperature for a short time or at lower temperature for a longer time, a decrease in the PeL from the bodies was observed and was related to the glasses crystallization. A decrease in the PeL from the bodies was also observed after immersion in simulated body fluid and was related to the mineralization of the sintered bodies. Therefore, we clearly show that by tracking the changes in the PeL overtime, these PeL bodies have a real potential application as biophotonic sensors to track dissolution and mineralization of the implant in the body.



中文翻译:

含有生物活性玻璃的持久发光颗粒:使用生物光子陶瓷追踪体内植入物矿化的前景

在本文中,我们证明了通过仔细选择烧结温度和持续时间可以获得持久的发光体。将硼硅酸盐和磷酸盐玻璃烧结成具有持久发光(PeL)SrAl 2 O 4:Eu 2 +,Dy 3+的物体停止辐射后长达数十小时会发出绿色光的微颗粒。当在高温下短时间烧结或在较低温度下较长时间烧结时,观察到来自主体的PeL降低,这与玻璃的结晶有关。浸入模拟体液后,还观察到人体中的PeL降低,这与烧结体的矿化有关。因此,我们清楚地表明,通过跟踪PeL随时间的变化,这些PeL体作为生物光子传感器来跟踪体内植入物的溶解和矿化具有真正的潜在应用。

更新日期:2017-08-24
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