The current obesity epidemic has focused a great deal of attention on cellular pathways of energy expenditure. While a crucial part of this process is diet-induced thermogenesis, the underlying mechanisms have remained unexplained. In this issue of Cell Metabolism, Kazak et al. (2017) describe a new thermogenic pathway in adipocytes that responds to diet overload, involving creatine cycling. These data suggest that this pathway might limit weight gain during overnutrition.

中文翻译：

---

肌酸助长了喂养的热效应。

当前的肥胖病流行已将大量注意力集中在能量消耗的细胞途径上。尽管这一过程的关键部分是饮食诱导的生热，但其潜在机制仍无法解释。在本期《细胞代谢》一书中，Kazak等人。（2017）描述了脂肪细胞中一种新的产热途径，该途径可响应饮食过量，涉及肌酸循环。这些数据表明，这种途径可能会限制营养过剩期间的体重增加。