The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.

中文翻译：

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Pleiotrophin的取向：编排脑胶质瘤脑侵袭。

侧脑室（LV）是脑肿瘤扩散的优先位置。但是，造成这种独特向性的指示性线索以前是未知的。在这个问题上，秦等人。阐明了潜在的机制，表明LV神经祖先分泌一种含多效性蛋白（PTN）的复合物，该复合物通过ROCK / Rho激活吸引神经胶质瘤细胞。