Acquired molecular changes can promote the spreading of primary tumor cells to distant tissues. In this issue of Cell, Roe et al. show that metastatic progression of pancreatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional program specifying early endodermal stem cells.

中文翻译：

---

重新编程增强剂以驱动转移。

获得性的分子变化可以促进原发性肿瘤细胞向远处组织的扩散。在《细胞》杂志上，Roe等人。研究表明，胰腺癌的转移进程涉及Foxa1进行的大规模增强子重编程，后者激活了指定早期内胚层干细胞的转录程序。