AbstractThe authors describe a rationally designed nanoprobe for the fluorometric determination of lysine. It is based on a ternary complex consisting of graphene oxide, aluminum ions (acting as a bridging agent), and alizarin red (GO-Al-AR). The fluorescence of the complex (with excitation/emission maxima at 440/512 nm) is weak but significantly enhanced upon the addition of lysine, probably due to a photoinduced electron transfer signalling mechanism. The method has a detection limit of 2 mg L−1 of lysine and a linear range from 25 mg L−1 to 250 mg L−1. It was applied to image lysine in human retinal pigment epithelium cells. Graphical abstractSchematic of a fluorescent nanosensor composed of graphene oxide, aluminum (III) ions and Alizarin Red to image lysine in human retinal pigment epithelium cells.

中文翻译：

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基于使用与氧化石墨烯共轭的茜素红铝 (III) 配合物的开启荧光赖氨酸纳米探针及其在赖氨酸细胞成像中的应用

摘要作者描述了一种用于赖氨酸荧光测定的合理设计的纳米探针。它基于由氧化石墨烯、铝离子（充当桥接剂）和茜素红 (GO-Al-AR) 组成的三元复合物。复合物的荧光（激发/发射最大值在 440/512 nm）很弱，但在添加赖氨酸后显着增强，这可能是由于光诱导电子转移信号机制。该方法的检测限为 2 mg L-1 赖氨酸，线性范围为 25 mg L-1 至 250 mg L-1。它被应用于人视网膜色素上皮细胞中赖氨酸的成像。图解摘要由氧化石墨烯、铝 (III) 离子和茜素红组成的荧光纳米传感器示意图，用于对人视网膜色素上皮细胞中的赖氨酸进行成像。