Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral response to replicate and propagate to new hosts. The complex regulation of the IFN response allows viruses to antagonize IFN at multiple levels. However, no single strategy appears to be the golden ticket, and viruses have adopted multiple means to dampen this host defense. This Review does not exhaustively cover all mechanisms of viral IFN antagonism. Rather it examines the ten most common strategies that viruses use to subvert the IFN response with examples from publications appearing in the last 10 years of Cell Host & Microbe. The virus-host interactions involved in induction and evasion of IFN represent a fertile area of research due to the significant large number of host and viral products that regulate this response, resulting in an intricate dance between hosts and their pathogens to achieve an optimal balance between virus replication, host disease, and survival.

中文翻译：

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病毒规避干扰素的十项策略。

感染脊椎动物宿主的病毒必须克服干扰素（IFN）介导的抗病毒反应，才能复制并传播到新的宿主中。IFN应答的复杂调节使病毒可以在多个水平上拮抗IFN。但是，似乎没有一个单一的策略是黄金招牌，并且病毒已采取多种手段来削弱这种主机防御能力。这篇综述没有详尽地涵盖病毒干扰素拮抗作用的所有机制。相反，它结合了Cell Host＆Microbe近十年来发表的出版物中的例子，研究了病毒用来破坏IFN反应的十种最常见策略。涉及诱导和逃逸IFN的病毒-宿主相互作用代表了一个肥沃的研究领域，因为有大量的宿主和病毒产物调节这种反应，