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The Helper T Cell’s Dilemma in Tuberculosis
Cell Host & Microbe ( IF 30.3 ) Pub Date : 2017-06-14 , DOI: 10.1016/j.chom.2017.06.004 Daniel L. Barber
中文翻译:
结核病中辅助性T细胞的困境
更新日期:2017-06-14
Cell Host & Microbe ( IF 30.3 ) Pub Date : 2017-06-14 , DOI: 10.1016/j.chom.2017.06.004 Daniel L. Barber
Vaccination approaches eliciting strong CD4 T cell responses provide only weak protection from tuberculosis. In this issue of Cell Host & Microbe, Moguche et al. (2017) show that T cells specific for different immunodominant vaccine antigens can fail to protect for opposite reasons, highlighting a major challenge in tuberculosis vaccine design.
中文翻译:
结核病中辅助性T细胞的困境
引起强烈的CD4 T细胞应答的疫苗接种方法只能提供抵抗结核病的弱效保护。在本期《细胞宿主与微生物》中,Moguche等人。(2017)表明,针对不同免疫优势疫苗抗原的T细胞可能由于相反的原因而无法保护,这突显了结核病疫苗设计的重大挑战。