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Relish the Thought and Channel Your Chloride, for Bacterial Clearance Depends on It
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2017-06-14 , DOI: 10.1016/j.chom.2017.05.013
Amanda J. Monahan , Neal Silverman

Macrophage-mediated bacterial clearance relies on phagocytic uptake of the pathogen, subsequent phagolysosomal maturation, and microbial degradation. In this issue of Cell Host & Microbe, Wong et al. (2017) report that a chloride transporter couples phagocytosis and bacterial clearance in an NF-κB-mediated feedforward loop, which is required for sustained pathogen uptake.



中文翻译:

享受思想并引导您的氯化物,因为细菌清除取决于它

巨噬细胞介导的细菌清除依赖于病原体的吞噬摄取,随后的吞噬溶酶体成熟和微生物降解。在本期《细胞宿主与微生物》中,Wong等人。(2017)报告说,氯化物转运蛋白在NF-κB介导的前馈环中结合吞噬作用和细菌清除作用,这是持续吸收病原体所必需的。

更新日期:2017-06-14
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