Macrophage-mediated bacterial clearance relies on phagocytic uptake of the pathogen, subsequent phagolysosomal maturation, and microbial degradation. In this issue of Cell Host & Microbe, Wong et al. (2017) report that a chloride transporter couples phagocytosis and bacterial clearance in an NF-κB-mediated feedforward loop, which is required for sustained pathogen uptake.

中文翻译：

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享受思想并引导您的氯化物，因为细菌清除取决于它

巨噬细胞介导的细菌清除依赖于病原体的吞噬摄取，随后的吞噬溶酶体成熟和微生物降解。在本期《细胞宿主与微生物》中，Wong等人。（2017）报告说，氯化物转运蛋白在NF-κB介导的前馈环中结合吞噬作用和细菌清除作用，这是持续吸收病原体所必需的。