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Nuclear Pore Complexes: A Scaffold Regulating Developmental Transcription?
Trends in Cell Biology ( IF 13.0 ) Pub Date : 2017-07-19 , DOI: 10.1016/j.tcb.2017.07.002
Atsushi Satomura , Jason H. Brickner

Nuclear pore complexes (NPCs) have a conserved, but poorly understood, role in transcriptional regulation. Recently, in Developmental Cell, Raices et al. argued that tissue-specific nuclear pore proteins (Nups) act as scaffolds that recruit the transcription factor Mef2C to the NPC, promoting transcription of NPC-associated genes during muscle development.



中文翻译:

核孔复合体:调控发育转录的支架吗?

核孔复合物(NPC)在转录调控中具有保守的作用,但知之甚少。最近,在《发育细胞》中,Raices等人。认为组织特异性核孔蛋白(Nups)充当将转录因子Mef2C募集到NPC的支架,从而在肌肉发育过程中促进NPC相关基因的转录。

更新日期:2017-07-19
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