Nuclear pore complexes (NPCs) have a conserved, but poorly understood, role in transcriptional regulation. Recently, in Developmental Cell, Raices et al. argued that tissue-specific nuclear pore proteins (Nups) act as scaffolds that recruit the transcription factor Mef2C to the NPC, promoting transcription of NPC-associated genes during muscle development.

中文翻译：

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核孔复合体：调控发育转录的支架吗？

核孔复合物（NPC）在转录调控中具有保守的作用，但知之甚少。最近，在《发育细胞》中，Raices等人。认为组织特异性核孔蛋白（Nups）充当将转录因子Mef2C募集到NPC的支架，从而在肌肉发育过程中促进NPC相关基因的转录。