Activated lymphocytes perform a clonal balancing act, yielding a daughter cell that differentiates owing to intense PI3K signaling, alongside a self-renewing sibling cell with blunted anabolic signaling. Divergent cellular anabolism versus catabolism is emerging as a feature of several developmental and regenerative paradigms. Metabolism can dictate cell fate, in part, because lineage-specific regulators are embedded in the circuitry of conserved metabolic switches. Unequal transmission of PI3K signaling during regenerative divisions is reminiscent of compartmentalized PI3K activity during directed motility or polarized information flow in non-dividing cells. The diverse roles of PI3K pathways in membrane traffic, cell polarity, metabolism, and gene expression may have converged to instruct sibling cell feast and famine, thereby enabling clonal differentiation alongside self-renewal.

活化的淋巴细胞执行克隆平衡作用，产生子细胞，该子细胞由于强烈的PI3K信号传导而分化，并伴随具有钝化合成代谢信号的自我更新同胞。发散的细胞合成代谢与分解代谢之间的关系正作为几种发展和再生范例的特征出现。代谢可以决定细胞的命运，部分原因是特定于谱系的调节剂嵌入了保守的代谢开关的电路中。再生分裂过程中PI3K信号的不均等传递使人联想到非分裂细胞在定向运动或极化信息流过程中分隔的PI3K活性。PI3K途径在膜运输，细胞极性，新陈代谢和基因表达中的不同作用可能已经融合在一起，以指导兄弟姐妹的细胞大餐和饥荒，