Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).

中文翻译：

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TREX1降低了癌症的免疫原性

Demaria及其同事最近确定了三种主要的修复核酸外切酶1（TREX1）作为癌细胞对单一高剂量辐射的有限免疫原性的关键决定因素。TREX1是开发新策略以增强由放射疗法（RT）驱动的抗癌免疫反应的有希望的目标。