Integrin activation is essential for cell adhesion and for connecting the extracellular matrix to the actin cytoskeleton. Thus, inappropriate integrin activation has been linked to several diseases, including cancer. Recent insights demonstrate that the main fibrillar adhesion component tensin maintains β1-integrin active in these mature adhesions. Depletion or silencing of AMP-activated protein kinase (AMPK), the energy sensor involved in maintaining the energy balance of the cell, enhances integrin activity by increasing the expression of tensin and thereby promoting cell adhesion, matrix formation, and mechanotransduction. Here, we discuss the role of tensin and AMPK in the regulation of integrin activity and integrin-dependent processes and their implication in diseases such as cancer and tissue fibrosis.

整联蛋白活化对于细胞粘附以及将细胞外基质连接至肌动蛋白细胞骨架至关重要。因此，不适当的整联蛋白活化与包括癌症在内的几种疾病有关。最近的见解表明，主要的纤维黏附成分张力蛋白在这些成熟的黏附中维持β1-整合素活性。AMP活化蛋白激酶（AMPK）的耗竭或沉默（涉及维持细胞能量平衡的能量传感器）通过增加肌腱蛋白的表达来增强整联蛋白活性，从而促进细胞粘附，基质形成和机械转导。在这里，我们讨论了张力蛋白和AMPK在整合素活性和整合素依赖性过程的调控中的作用，以及它们在诸如癌症和组织纤维化等疾病中的意义。