Identified as a TP53-binding protein, 53BP1 is a key regulator of the cellular response to double-strand breaks, a TP53-independent activity. Recent data have established a new TP53-dependent function for 53BP1 in mitotic surveillance after centrosome loss.

中文翻译：

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TP53和53BP1团聚

被鉴定为TP53结合蛋白的53BP1是细胞对双链断裂（一种不依赖TP53的活性）的反应的关键调节剂。最近的数据建立了新的TP53依赖性功能，在中心体丢失后有丝分裂监视中具有53BP1。