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Loss of Brain Aerobic Glycolysis in Normal Human Aging.
Cell Metabolism ( IF 27.7 ) Pub Date : 2017-Aug-01 , DOI: 10.1016/j.cmet.2017.07.010
Manu S Goyal 1 , Andrei G Vlassenko 2 , Tyler M Blazey 3 , Yi Su 2 , Lars E Couture 3 , Tony J Durbin 3 , Randall J Bateman 4 , Tammie L-S Benzinger 2 , John C Morris 4 , Marcus E Raichle 2
Affiliation  

The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we describe PET-based measurements of brain glucose uptake, oxygen utilization, and blood flow in cognitively normal adults from 20 to 82 years of age. Age-related decreases in brain glucose uptake exceed that of oxygen use, resulting in loss of brain aerobic glycolysis (AG). Whereas the topographies of total brain glucose uptake, oxygen utilization, and blood flow remain largely stable with age, brain AG topography changes significantly. Brain regions with high AG in young adults show the greatest change, as do regions with prolonged developmental transcriptional features (i.e., neoteny). The normal aging human brain thus undergoes characteristic metabolic changes, largely driven by global loss and topographic changes in brain AG.

中文翻译:


正常人类衰老过程中大脑有氧糖酵解的丧失。



正常衰老的人脑会经历新陈代谢的整体下降,但这是否会影响大脑代谢的拓扑结构尚不清楚。在这里,我们描述了基于 PET 的 20 至 82 岁认知正常成年人的大脑葡萄糖摄取、氧利用率和血流量测量。与年龄相关的大脑葡萄糖摄取量的减少超过了氧气消耗的减少,导致大脑有氧糖酵解(AG)的丧失。尽管大脑总葡萄糖摄取、氧利用率和血流量的分布随年龄的增长而基本保持稳定,但大脑 AG 的分布却发生了显着变化。年轻人中具有高 AG 的大脑区域显示出最大的变化,具有长期发育转录特征(即幼态持续期)的区域也是如此。因此,正常衰老的人脑会经历特征性的代谢变化,这主要是由大脑 AG 的整体损失和地形变化驱动的。
更新日期:2017-08-24
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