Despite widespread consumption of non-nutritive sweeteners (NNSs), the impact of manipulating the perceived sweetness of food is unclear. Previously we reported that chronic consumption of the NNSs sucralose or L-glucose led to increased calories consumed post-exposure; however, a recent study suggested this effect occurs because NNSs acutely suppress food intake, leading to a caloric debt. Here we show that acute ingestion of sucralose in the context of a low-carbohydrate diet causes a pronounced increase in calories consumed. Moreover, neither sucralose nor L-glucose had a lasting effect on food intake during chronic exposure; however, both NNSs enhance food intake post-exposure. Together these data confirm that sucralose and L-glucose promote food intake under a variety of experimental conditions.

中文翻译：

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慢性三氯蔗糖或L-葡萄糖摄入不会抑制食物摄入。

尽管非营养性甜味剂（NNS）的广泛消费，但尚不清楚操纵食物的甜度的影响。先前我们曾报道，长期食用NNS的三氯蔗糖或L-葡萄糖会导致暴露后所消耗的卡路里增加。然而，最近的一项研究表明，这种效果之所以发生是因为NNS会严重抑制食物摄入，从而导致卡路里债务。在这里，我们表明在低碳水化合物饮食的情况下急性摄入三氯半乳蔗糖会导致所消耗的卡路里显着增加。此外，三氯半乳蔗糖和L-葡萄糖都不会对长期暴露过程中的食物摄入产生持久影响。但是，两个NNS都会增加暴露后的食物摄入量。这些数据加在一起证实三氯蔗糖和L-葡萄糖可以在多种实验条件下促进食物摄入。