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Plasticity of Cell Migration In Vivo and In Silico
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2016-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-111315-125201
Veronika te Boekhorst 1 , Luigi Preziosi 2 , Peter Friedl 1, 3, 4
Affiliation  

Cell migration results from stepwise mechanical and chemical interactions between cells and their extracellular environment. Mechanistic principles that determine single-cell and collective migration modes and their interconversions depend upon the polarization, adhesion, deformability, contractility, and proteolytic ability of cells. Cellular determinants of cell migration respond to extracellular cues, including tissue composition, topography, alignment, and tissue-associated growth factors and cytokines. Both cellular determinants and tissue determinants are interdependent; undergo reciprocal adjustment; and jointly impact cell decision making, navigation, and migration outcome in complex environments. We here review the variability, decision making, and adaptation of cell migration approached by live-cell, in vivo, and in silico strategies, with a focus on cell movements in morphogenesis, repair, immune surveillance, and cancer metastasis.

中文翻译:


体内和计算机上细胞迁移的可塑性

细胞迁移是由细胞及其细胞外环境之间逐步的机械和化学相互作用导致的。确定单细胞和集体迁移模式及其相互转换的机制原理取决于细胞的极化,粘附,可变形性,收缩性和蛋白水解能力。细胞迁移的细胞决定因素对细胞外线索有反应,包括组织组成,形貌,排列以及与组织相关的生长因子和细胞因子。细胞决定簇和组织决定簇都是相互依赖的。进行相互调整;并共同影响复杂环境中的电池决策,导航和迁移结果。我们在这里回顾了活细胞,体内和计算机模拟策略所涉及的细胞迁移的变异性,决策制定和适应性,

更新日期:2016-10-06
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