Compatibility of Nitric Oxide Release with Implantable Enzymatic Glucose Sensors Based on Osmium (III/II) Mediated Electrochemistry,ACS Sensors

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Compatibility of Nitric Oxide Release with Implantable Enzymatic Glucose Sensors Based on Osmium (III/II) Mediated Electrochemistry
ACS Sensors ( IF 8.2 ) Pub Date : 2017-08-23 00:00:00 , DOI: 10.1021/acssensors.7b00430
Kyoung Ha Cha ₁ , Mark E. Meyerhoff ₁

Affiliation

The compatibility of nitric oxide (NO) release coatings with implantable enzymatic glucose sensors based on osmium (III/II) mediated electrochemical detection is examined for the first time. NO-releasing osmium-mediated glucose sensors are prepared using a S-nitrosothiol impregnated outer tubing and are tested in vitro in both phosphate buffer (pH 7.4) and whole porcine blood. It is demonstrated that after 3 days of continuous NO release at or above physiological levels, there are no negative effects on the osmium mediated electrochemical currents. Indeed, such sensors maintain their functionality, sensitivity, and accuracy for detecting glucose levels in blood. The results suggest that improved performance of both intravascular and, potentially, subcutaneous Os(III/II) mediated glucose sensors may be realized by taking advantage of NO’s well-known anticlotting, anti-inflammatory, and antimicrobial properties.

中文翻译：

一氧化氮释放与基于O（III / II）介导的电化学植入式葡萄糖传感器的兼容性

首次研究了基于（III / II）介导的电化学检测的一氧化氮（NO）释放涂层与可植入酶葡萄糖传感器的相容性。使用S制备释放NO的-介导的葡萄糖传感器-亚硝基硫醇浸渍的外管，并在磷酸盐缓冲液（pH 7.4）和全猪血中进行了体外测试。结果表明，连续三天连续释放NO达到或高于生理水平后，对on介导的电化学电流没有负面影响。实际上，这种传感器保持其功能，灵敏度和准确性，以检测血液中的葡萄糖水平。结果表明，利用NO众所周知的抗凝血，抗炎和抗菌特性，可以实现血管内和潜在的皮下Os（III / II）介导的葡萄糖传感器的性能提高。

更新日期：2017-08-24

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