Abstract

A range of N-benzylic and N-phenethylic ephedrine derivatives were prepared in a one-pot procedure starting from the two enantiomers of ephedrine using the Potier reagent, and a polyfunctional aryl- or benzylic organozinc halide. The biological activity in indatraline MS Binding Assays addressing hDAT, hNET and hSERT was determined and discussed.

A range of N-benzylic and N-phenethylic ephedrine derivatives were prepared in a one-pot procedure starting from the two enantiomers of ephedrine using the Potier reagent, and a polyfunctional aryl- or benzylic organozinc halide. The biological activity in indatraline MS Binding Assays addressing hDAT, hNET and hSERT was determined and discussed.

中文翻译：

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新型N-苄基和N-苯乙基麻黄碱衍生物的合成及生物活性

摘要

使用Potier试剂从麻黄碱的两种对映体开始，通过一锅法制备一系列N-苄基和N-苯乙基麻黄碱衍生物，以及多官能芳基或苄基有机锌卤化物。确定并讨论了indatraline MS结合测定法中针对hDAT，hNET和hSERT的生物活性。

使用Potier试剂从麻黄碱的两种对映体开始，通过一锅法制备一系列N-苄基和N-苯乙基麻黄碱衍生物，以及多官能芳基或苄基有机锌卤化物。确定并讨论了indatraline MS结合测定法中针对hDAT，hNET和hSERT的生物活性。