As antimicrobial resistance becomes a reality, treatment of patients with infections most effectively within stewardship principles is a growing challenge. Although stewardship programmes provide guidance regarding individual dosing and frequency or duration of treatment, it is seldom done through the lens of pharmacokinetic (PK)-pharmacodynamic (PD) principles. In today's clinical setting, each patient has multiple parameters which must be integrated concurrently. Each patient differs in many respects, not least of which include the species and susceptibility of pathogen(s), organ function, and concomitant medications.

中文翻译：

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PK-PD Compass，新型计算机决策支持系统

随着抗菌素耐药性的实现，在管理原则范围内最有效地治疗感染患者已成为一个日益严峻的挑战。尽管管理计划会提供有关个人剂量，治疗频率或持续时间的指导，但很少通过药代动力学（PK）-药效学（PD）原理来完成。在当今的临床环境中，每个患者都有多个必须同时集成的参数。每个患者在很多方面都有不同之处，其中不仅包括病原体的种类和易感性，器官功能以及随之而来的药物。