Belén Gutiérrez-Gutiérrez and colleagues¹ investigated the effect of appropriate combination therapy versus monotherapy on the mortality of patients with bloodstream infections (BSIs) due to carbapenemase-producing Enterobacteriaceae (CPE) in The Lancet Infectious Diseases. In stratified analyses, appropriate combination therapy was associated with a significantly lower mortality than was appropriate monotherapy in the high-mortality-score stratum (adjusted hazard ratio 0·56, 95% CI 0·34–0·91; p=0·02), yet the low-mortality-score stratum showed no benefit (adjusted odds ratio 1·21, 0·56–2·56; p=0·62).

中文翻译：

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产生碳青霉烯酶的肠杆菌科的联合治疗：对耐药性的增加作用尚不清楚

BelénGutiérrez-Gutiérrez及其同事¹研究了适当的联合治疗与单一治疗对柳叶刀感染性疾病中由产生碳青霉烯酶的肠杆菌科（CPE）引起的血流感染（BSI）患者死亡率的影响。在分层分析中，在高死亡率得分层中，适当的联合治疗比适当的单一治疗显着降低死亡率（调整后的危险比0·56、95％CI 0·34-0·91； p = 0·02 ），但低死亡率分数层没有显示出任何好处（调整后的优势比为1·21、0·56-2·56； p = 0·62）。