Despite all efforts, the burden of disease caused by multidrug-resistant (MDR) tuberculosis is worrisome. In The Lancet Infectious Diseases, Aditya Sharma and colleagues¹ estimated an increase in MDR and extensively drug-resistant tuberculosis and a shift from acquired drug resistance to transmission of resistance.¹ In the accompanying Comment, Andrei Mariandyshev and Platon Eliseev² emphasised implementation of the short-course regimen as the most important measure to prevent the spread of MDR tuberculosis.

中文翻译：

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耐多药结核病：药代动力学和药效学

尽管做出了所有努力，但由多药耐药性（MDR）结核病引起的疾病负担令人担忧。在《柳叶刀传染病》中，Aditya Sharma及其同事¹估计了MDR和广泛耐药性结核病的增加以及从获得性耐药性向耐药性传播的转变。¹在随附的评论中，Andrei Mariandyshev和Platon Eliseev ²强调了实施短期治疗方案是防止MDR结核病传播的最重要措施。