Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. Marine Sponge,Journal of Natural Products

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Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. Marine Sponge
Journal of Natural Products ( IF 5.1 ) Pub Date : 2017-08-23 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00435
Jie Wang ₁ , Feng-Rong Mu _{2,

3} , Wei-Hua Jiao ₂ , Jian Huang ₁ , Li-Li Hong ₂ , Fan Yang ₂ , Ying Xu ₂ , Shu-Ping Wang ₂ , Fan Sun ₂ , Hou-Wen Lin _{1,

2}

Affiliation

Three new meroterpenoids, hyrtiolacton A (1), nakijinol F (2), and nakijinol G (3), along with three known ones, nakijinol B (4), nakijinol E (5), and dactyloquinone A (6), were isolated and characterized from a Hyrtios sp. marine sponge collected from the South China Sea. The new structures were determined based on extensive analysis of HRESIMS and NMR data, and their absolute configurations were assigned by a combination of single-crystal X-ray diffraction and electronic circular dichroism analyses. Hyrtiolacton A (1) represents an unprecedented meroterpenoid featuring an unusual 2-pyrone attached to the sesquiterpene core, which is the first example of a pyrone-containing 4,9-friedodrimane-type sesquiterpene. These compounds were evaluated for their protein tyrosine phosphatase (PTP1B) inhibitory and cytotoxic activities. Nakijinol G (3) showed PTP1B inhibitory activity with an IC₅₀ value of 4.8 μM but no cytotoxicity against four human cancer cell lines.

更新日期：2017-08-23

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