Miniprotein Design: Past, Present, and Prospects,Accounts of Chemical Research

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Miniprotein Design: Past, Present, and Prospects
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-08-23 00:00:00 , DOI: 10.1021/acs.accounts.7b00186
Emily G. Baker ₁ , Gail J. Bartlett ₁ , Kathryn L. Porter Goff ₁ , Derek N. Woolfson _{1,

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Affiliation

The design and study of miniproteins, that is, polypeptide chains <40 amino acids in length that adopt defined and stable 3D structures, is resurgent. Miniproteins offer possibilities for reducing the complexity of larger proteins and so present new routes to studying sequence-to-structure and sequence-to-stability relationships in proteins generally. They also provide modules for protein design by pieces and, with this, prospects for building more-complex or even entirely new protein structures. In addition, miniproteins are useful scaffolds for templating functional domains, for example, those involved in protein–protein interactions, catalysis, and biomolecular binding, leading to potential applications in biotechnology and medicine.

中文翻译：

微蛋白设计：过去，现在和前景

微型蛋白质的设计和研究是复兴的，微型蛋白质即长度小于40个氨基酸的多肽链采用确定的和稳定的3D结构。微型蛋白质为降低较大蛋白质的复杂性提供了可能性，因此为研究蛋白质中序列与结构以及序列与稳定性之间的关系提供了新的途径。它们还为蛋白质的逐段设计提供了模块，从而为构建更复杂甚至全新的蛋白质结构提供了前景。此外，微蛋白对于模板化功能域是有用的支架，例如，涉及蛋白质-蛋白质相互作用，催化和生物分子结合的功能域，从而导致在生物技术和医学中的潜在应用。

更新日期：2017-08-23

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