Activation of Engineered Protein Tyrosine Phosphatases with the Biarsenical Compound AsCy3-EDT2,ChemBioChem

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Activation of Engineered Protein Tyrosine Phosphatases with the Biarsenical Compound AsCy3-EDT2
ChemBioChem ( IF 2.6 ) Pub Date : 2017-08-23 05:15:59 , DOI: 10.1002/cbic.201700253
Wai Cheung Chan ₁ , Gregory S. Knowlton ₁ , Anthony C. Bishop ₁

Affiliation

Turn it up: Cysteine point mutations on the WPD loop generated protein tyrosine phosphatase (PTP) mutants that could be target-specifically activated with the small molecule AsCy3. Given the strict conservation of the WPD loop across the classical PTP family, this strategy for direct chemical control over enzyme activity could be applicable to a range of signaling proteins.

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