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Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-06-20 00:00:00 , DOI: 10.1039/c7qo00416h
Liu-Hai Wu 1, 2, 3, 4, 5 , Kai Zhao 6, 7, 8, 9, 10 , Zhi-Liang Shen 6, 7, 8, 9, 10 , Teck-Peng Loh 6, 7, 8, 9, 10
Affiliation  

An efficient copper(I)-catalyzed trifluoromethylation of styrene derivatives using CF3SO2Na as a trifluoromethylating source in the presence of tBuOOtBu has been developed. Mechanistic studies show that the reaction likely proceeds via a radical pathway, providing a general and straightforward access to trifluoromethylated styrene derivatives. Advantageously, excellent stereoselectivity is obtained with styrene derivatives in this transformation.

中文翻译:

铜衍生物与CF 3 SO 2 Na的苯乙烯衍生物的三氟甲基化

已经开发出在t BuOO t Bu存在下使用CF 3 SO 2 Na作为三氟甲基化源的苯乙烯的有效铜(I)催化的三氟甲基化。机理研究表明,该反应可能通过自由基途径进行,从而提供了直接直接获得三氟甲基化苯乙烯衍生物的途径。有利地,在该转化中用苯乙烯衍生物获得了优异的立体选择性。
更新日期:2017-08-23
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