Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na,Organic Chemistry Frontiers

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Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-06-20 00:00:00 , DOI: 10.1039/c7qo00416h
Liu-Hai Wu _{1,

2,

3,

4,

5} , Kai Zhao _{6,

7,

8,

9,

10} , Zhi-Liang Shen _{6,

7,

8,

9,

10} , Teck-Peng Loh _{6,

7,

8,

9,

10}

Affiliation

An efficient copper(I)-catalyzed trifluoromethylation of styrene derivatives using CF₃SO₂Na as a trifluoromethylating source in the presence of ^tBuOO^tBu has been developed. Mechanistic studies show that the reaction likely proceeds via a radical pathway, providing a general and straightforward access to trifluoromethylated styrene derivatives. Advantageously, excellent stereoselectivity is obtained with styrene derivatives in this transformation.

中文翻译：

铜衍生物与CF ₃ SO ₂ Na的苯乙烯衍生物的三氟甲基化

已经开发出在^t BuOO ^t Bu存在下使用CF ₃ SO ₂ Na作为三氟甲基化源的苯乙烯的有效铜（I）催化的三氟甲基化。机理研究表明，该反应可能通过自由基途径进行，从而提供了直接直接获得三氟甲基化苯乙烯衍生物的途径。有利地，在该转化中用苯乙烯衍生物获得了优异的立体选择性。

更新日期：2017-08-23

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