A modular approach to highly functionalized 3-sulfonylfurans via conjugate addition of 3-cyclopropylideneprop-2-en-1-ones with sodium sulfinates and sequential 5-endo-trig iodocyclization,Organic Chemistry Frontiers

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A modular approach to highly functionalized 3-sulfonylfurans via conjugate addition of 3-cyclopropylideneprop-2-en-1-ones with sodium sulfinates and sequential 5-endo-trig iodocyclization
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-06-14 00:00:00 , DOI: 10.1039/c7qo00362e
Maozhong Miao _{1,

2,

3,

4} , Huaping Xu _{1,

2,

3,

4} , Yi Luo _{1,

2,

3,

4} , Mengchao Jin _{1,

2,

3,

4} , Zhengkai Chen _{1,

2,

3,

4} , Jianfeng Xu _{1,

2,

3,

4} , Hongjun Ren _{1,

2,

3,

4}

Affiliation

A highly efficient conjugate addition and 5-endo-trig cyclization reaction of 3-cyclopropylideneprop-2-en-1-ones with sodium sulfinates in the presence of iodine is described. A wide variety of densely functionalized 3-sulfonylfurans are furnished by single-step and one-pot methods, respectively. The results of such postcyclization modifications are also presented.

中文翻译：

通过将3-环亚丙基丙-2-烯-1-酮与亚磺酸钠共轭加成和依次进行5-内-trig碘化环化反应的方法，以高度模块化的方式合成高度官能化的3-磺酰基呋喃

描述了在碘存在下3-亚环丙基-亚丙基丙-2-烯-1-酮与亚磺酸钠的高效共轭加成和5-内-trig环化反应。一步法和一锅法分别提供了多种稠密官能化的3-磺酰基呋喃。还介绍了此类环化后的结果。

更新日期：2017-08-23

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