Silver-catalyzed cyclization of nitrones with 2-azetine: a radical approach to 2,3-disubstituted quinolines,Organic Chemistry Frontiers

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Silver-catalyzed cyclization of nitrones with 2-azetine: a radical approach to 2,3-disubstituted quinolines
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-06-12 00:00:00 , DOI: 10.1039/c7qo00405b
Hao Yan _{1,

2,

3,

4,

5} , Xincheng Li _{1,

2,

3,

4} , Chunxiang Wang _{1,

2,

3,

4} , Boshun Wan _{1,

2,

3,

4}

Affiliation

A silver-catalyzed intermolecular tandem cyclization of nitrones with 2-azetine was developed for the synthesis of 2,3-disubstituted quinolines under mild conditions with good yields. This approach features a C–N bond cleavage of 2-azetine and an N–O bond cleavage of nitrones via a radical pathway. The results of this study provide a new reaction pattern for nitrones and may find applications in the synthesis of other heterocycles.

中文翻译：

银与2-氮杂环丁烷的银催化环化反应：2,3-二取代喹啉的自由基方法

开发了银催化的2-氮杂环丁烷的分子间串联环化反应，可在温和条件下以良好的收率合成2,3-二取代的喹啉。该方法的特点是通过自由基途径将2-氮杂环丁烷进行C–N键断裂，并通过硝化基团的N–O键断裂。这项研究的结果为硝酮提供了一种新的反应模式，并可能在其他杂环的合成中找到应用。

更新日期：2017-08-23

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