pH-responsive amphiphilic triblock copolymer derived from poly (ethylene glycol), poly (acrylamide) and poly (lactide) has been synthesized through the consecutive routes of ATRP, ROP and Click chemistry. Controlled nature of the triblock copolymer has been affirmed by the GPC analysis. Structural property and gelling nature of the copolymer have been investigated using FTIR, ¹H/¹³C NMR spectral analyses and rheological characteristics. The synthesized copolymer is amphiphilic in nature that results to the formation of self-aggregation of the polymeric chains. The nanostructure micelle has been characterized further through AFM, FESEM and HR-TEM analyses. Encapsulation of fluorescence probe guest molecule (pyrene) into copolymer micelle and its release behaviour reveals that it is pH-stimulated and shows sustained release behaviour at pH 7.4.

通过连续的ATRP，ROP和Click化学方法合成了由聚乙二醇，聚丙烯酰胺和丙交酯衍生的具有pH响应的两亲性三嵌段共聚物。通过GPC分析证实了三嵌段共聚物的受控性质。已使用FTIR，¹ H / ¹³研究了共聚物的结构性质和胶凝性质C NMR光谱分析和流变特性。合成的共聚物本质上是两亲的，导致形成聚合物链的自聚集。通过AFM，FESEM和HR-TEM分析进一步表征了纳米结构胶束。将荧光探针客体分子（py）包封到共聚物胶束中，并且其释放行为表明它是受pH刺激的，并且在pH 7.4下显示出持续释放行为。