Abstract

A simple and efficient copper-catalyzed S-arylation of aryl­thioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

A simple and efficient copper-catalyzed S-arylation of aryl­thioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

中文翻译：

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铜催化的CS交叉偶联反应：芳基硫脲的S-芳基化

摘要

开发了一种简单有效的铜催化的芳基硫脲的S-芳基化反应。通过铜催化的S-芳基化，芳硫基脲被顺利地转化为芳基-异硫脲，并具有良好的收率。该方法的特点包括使用无配体的催化剂，收率好，反应时间短和底物范围广。该方法提供了一些潜在的生物活性化合物的简便的制备方法。

开发了一种简单有效的铜催化的芳基硫脲的S-芳基化反应。通过铜催化的S-芳基化，芳硫基脲被顺利地转化为芳基-异硫脲，并具有良好的收率。该方法的特点包括使用无配体的催化剂，收率好，反应时间短和底物范围广。该方法提供了一些潜在的生物活性化合物的简便的制备方法。