Synthesis ( IF 2.2 ) Pub Date : 2017-08-22 , DOI: 10.1055/s-0036-1590879 Hui Zhu 1 , Xing Liu 1 , Cai-Zhu Chang 1 , Zhi-Bing Dong 1, 2
Abstract
A simple and efficient copper-catalyzed S-arylation of arylthioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.
A simple and efficient copper-catalyzed S-arylation of arylthioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.
中文翻译:
铜催化的CS交叉偶联反应:芳基硫脲的S-芳基化
摘要
开发了一种简单有效的铜催化的芳基硫脲的S-芳基化反应。通过铜催化的S-芳基化,芳硫基脲被顺利地转化为芳基-异硫脲,并具有良好的收率。该方法的特点包括使用无配体的催化剂,收率好,反应时间短和底物范围广。该方法提供了一些潜在的生物活性化合物的简便的制备方法。
开发了一种简单有效的铜催化的芳基硫脲的S-芳基化反应。通过铜催化的S-芳基化,芳硫基脲被顺利地转化为芳基-异硫脲,并具有良好的收率。该方法的特点包括使用无配体的催化剂,收率好,反应时间短和底物范围广。该方法提供了一些潜在的生物活性化合物的简便的制备方法。