Advances in genomics technology have provided the means to probe myriad chromatin interactions at unprecedented spatial and temporal resolution. This has led to a profound understanding of nucleosome organization within the genome, revealing that nucleosomes are highly dynamic. Nucleosome dynamics are governed by a complex interplay of histone composition, histone post-translational modifications, nucleosome occupancy and positioning within chromatin, which are influenced by numerous regulatory factors, including general regulatory factors, chromatin remodellers, chaperones and polymerases. It is now known that these dynamics regulate diverse cellular processes ranging from gene transcription to DNA replication and repair.

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了解核小体动力学及其与基因表达和DNA复制的联系

基因组学技术的进步提供了以空前的时空分辨率探测无数染色质相互作用的方法。这导致了对基因组内核小体组织的深刻理解，揭示了核小体是高度动态的。核小体动力学受组蛋白组成，组蛋白翻译后修饰，核小体占有率和染色质内位置的复杂相互作用影响，这些因素受许多调节因素影响，包括一般调节因素，染色质重塑剂，伴侣蛋白和聚合酶。现在已知这些动力学调节从基因转录到DNA复制和修复的多种细胞过程。