Multilayered Polysaccharide Nanofilms for Controlled Delivery of Pentoxifylline and Possible Treatment of Chronic Venous Ulceration,Biomacromolecules

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Multilayered Polysaccharide Nanofilms for Controlled Delivery of Pentoxifylline and Possible Treatment of Chronic Venous Ulceration
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-08-22 00:00:00 , DOI: 10.1021/acs.biomac.7b00523
Jan Stana ₁ , Janja Stergar ₂ , Lidija Gradišnik ₂ , Vojko Flis ₃ , Rupert Kargl ₄ , Eleonore Fröhlich ₅ , Karin Stana Kleinschek ₄ , Tamilselvan Mohan ₆ , Uroš Maver _{2,

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Affiliation

Local drug delivery systems made from nontoxic polysaccharide nanofilms have an enormous potential in wound care. A detailed understanding of the structural, surface, physicochemical, and cytotoxic properties of such systems is crucial to design clinically efficacious materials. Herein, we fabricated polysaccharide-based nanofilms onto either a 2D model (SiO₂ and Au sensors) or on nonwoven alginate 3D substrates using an alternating assembly of N,N,N-trimethylchitosan (TMC) and alginic acid (ALG) by a spin-assisted layer-by-layer (LbL) technique. These TMC/ALG multilayered nanofilms are used for a uniform encapsulation and controlled release of pentoxifylline (PTX), a potent anti-inflammatory drug for treatment of the chronic venous ulceration. We show a tailorable film growth and mass, morphology, as well as surface properties (charge, hydrophilicity, porosity) of the assembled nanofilms through control of the coating during the spin-assisted assembly. The uniform distribution of the encapsulated PTX in the TMC/ALG nanofilms is preserved even with when the amount of the incorporated PTX increases. The PTX release mechanism from the model and real systems is studied in detail and is very comparable for both systems. Finally, different cell-based assays illustrated the potential of the TMC/ALG multilayer system in wound care (e.g., treatment chronic venous ulceration) applications, including a decrease of TNF-α secretion, a common indicator of inflammation.

中文翻译：

多层多糖纳米膜可控制己酮可可碱的递送及对慢性静脉溃疡的可能治疗

由无毒多糖纳米膜制成的局部药物递送系统在伤口护理方面具有巨大潜力。对此类系统的结构，表面，物理化学和细胞毒性特性的详细了解对于设计临床上有效的材料至关重要。在这里，我们使用N，N，N的交替组装在2D模型（SiO ₂和Au传感器）或无纺藻酸盐3D基板上制造了基于多糖的纳米膜。-三甲基壳聚糖（TMC）和藻酸（ALG）通过旋转辅助逐层（LbL）技术进行。这些TMC / ALG多层纳米膜用于均匀包封和控制释放己酮可可碱（PTX），后者是一种有效的消炎药，用于治疗慢性静脉溃疡。我们通过在旋转辅助组装过程中控制涂层，显示了可调节的膜生长和可组装的纳米膜的质量，形态以及表面性质（电荷，亲水性，孔隙率）。即使当掺入的PTX的量增加时，仍保留了包封的PTX在TMC / ALG纳米膜中的均匀分布。对模型和实际系统中的PTX释放机制进行了详细研究，并且对于这两个系统都具有可比性。最后，

更新日期：2017-08-23

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