Hematopoietic stem cell transplantation (HSCT) is an important therapy for patients with a variety of hematological malignancies. HSCT would be greatly improved if patient-specific hematopoietic stem cells (HSCs) could be generated from induced pluripotent stem cells in vitro. There is an incomplete understanding of the genes and signals involved in HSC induction, migration, maintenance, and niche engraftment. Recent studies in zebrafish have revealed novel genes that are required for HSC induction and niche regulation of HSC homeostasis. Manipulation of these signaling pathways and cell types may improve HSC bioengineering, which could significantly advance critical, lifesaving HSCT therapies.

造血干细胞移植（HSCT）是治疗多种血液恶性肿瘤患者的重要疗法。如果能够在体外从诱导多能干细胞生成患者特异性造血干细胞（HSC），HSCT 将得到极大改善。目前对 HSC 诱导、迁移、维持和微环境植入所涉及的基因和信号的了解还不完全。最近对斑马鱼的研究揭示了 HSC 诱导和 HSC 稳态调节所需的新基因。操纵这些信号通路和细胞类型可能会改善 HSC 生物工程，从而显着推进关键的、挽救生命的 HSCT 疗法。