Introduction of 2,6-Diaminopurines into Serinol Nucleic Acid Improves Anti-miRNA Performance,ChemBioChem

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Introduction of 2,6-Diaminopurines into Serinol Nucleic Acid Improves Anti-miRNA Performance
ChemBioChem ( IF 2.6 ) Pub Date : 2017-08-22 11:40:22 , DOI: 10.1002/cbic.201700272
Yukiko Kamiya ₁ , Yuka Donoshita ₁ , Hiroshi Kamimoto ₁ , Keiji Murayama ₁ , Jumpei Ariyoshi _{1,

2} , Hiroyuki Asanuma ₁

Affiliation

Finding the best position: Anti-miRNA oligonucleotide (AMO) made by an artificial nucleic acid, serinol nucleic acid, shows remarkable nucleic-acid resistance. Increasing the affinity to the seed and tail regions of miRNA by the introduction of 2,6-diaminopurine into AMO improves its activity.

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