Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death,Molecular BioSystems

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Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death
Molecular BioSystems Pub Date : 2017-06-28 00:00:00 , DOI: 10.1039/c7mb00191f
T. Takatani-Nakase _{1,

2,

3,

4} , M. Katayama _{4,

5,

6,

7,

8} , C. Matsui _{1,

2,

3,

4} , K. Hanaoka _{4,

9,

10,

11} , A. J. van der Vlies _{12,

13,

14,

15} , K. Takahashi _{1,

2,

3,

4} , I. Nakase _{4,

5,

6,

7,

8} , U. Hasegawa _{12,

13,

14,

15}

Affiliation

Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H₂S donor micelle releases H₂S intracellularly and prevents cardiomyocyte apoptosis in an in vitro ischemia model.

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