Small molecule-induced cellular conversion,Chemical Society Reviews

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Small molecule-induced cellular conversion
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-08-22 00:00:00 , DOI: 10.1039/c7cs00330g
Debojyoti De _{1,

2,

3,

4} , Debasish Halder _{4,

5,

6,

7} , Injae Shin _{4,

5,

6,

7} , Kyeong Kyu Kim _{1,

2,

3,

4,

8}

Affiliation

Over the last decade, the development of methods to promote conversion of one type of cell to a specific type of another cell (or change of cell fate) has received great attention in basic biological research and therapeutic applications. A precise, reproducible and safe protocol for inducing this change is a prerequisite for cellular conversion. Although genetic manipulation, which relies on the introduction of specific genes into cells, is a promising approach, the results of initial investigations have highlighted serious safety concerns associated with forced ectopic gene expression with unpredictable side effects. Alternatively, a chemical approach that relies on the use of small molecules to modulate the cell fate has great potential in terms of precise control and clinical safety. In addition, the ease of application, reproducibility and scalability are features that make a small molecule-based approach an extraordinary resource for this purpose. In this review we summarize methods which have been devised to identify small molecules that induce cellular conversion and highlight recent advances made using small molecule modulators to induce changes in the fate of cells.

中文翻译：

小分子诱导的细胞转化

在过去的十年中，促进一种类型的细胞转化为另一种类型的特定细胞（或改变细胞命运）的方法的开发在基础生物学研究和治疗应用中受到了极大的关注。诱导这种变化的精确，可复制和安全的方案是细胞转化的先决条件。尽管依赖特定基因导入细胞的遗传操作是一种有前途的方法，但初步研究的结果突出了与强制异位基因表达相关的严重安全性问题，且副作用不可预测。备选地，在精确控制和临床安全性方面，依赖于使用小分子来调节细胞命运的化学方法具有巨大的潜力。此外，易于应用，重现性和可扩展性是使基于小分子的方法成为用于此目的的非凡资源的功能。在这篇综述中，我们总结了设计用于鉴定诱导细胞转化的小分子的方法，并重点介绍了使用小分子调节剂诱导细胞命运变化的最新进展。

更新日期：2017-08-22

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