A continuous flow method for the selective reduction of aromatic nitriles to the corresponding amine is reported. The method is based on a ruthenium-catalysed transfer-hydrogenation process, requires no additives, and uses isopropanol as both solvent and reducing agent. The process utilizes 1 mol% of the commercially available [Ru( p -cymene)Cl 2 ] 2 , with a residence time of ca. 9 min, and a throughput of 50 mmol/h. The method was successfully applied to a range of aromatic nitriles providing the corresponding primary amines in good yields.

中文翻译：

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快速连续钌催化芳香腈转移氢化成伯胺

报道了一种将芳香腈选择性还原为相应胺的连续流动方法。该方法基于钌催化的转移加氢过程，不需要添加剂，并使用异丙醇作为溶剂和还原剂。该工艺使用 1 mol% 的市售 [Ru(p-cymene)Cl 2 ] 2 ，停留时间约为 9 分钟，吞吐量为 50 毫摩尔/小时。该方法成功应用于一系列芳族腈，以良好的收率提供相应的伯胺。