The roles of the hippocampus and prefrontal cortex (PFC) in memory processing — individually or in concert — are a major topic of interest in memory research. These brain areas have distinct and complementary roles in episodic memory, and their interactions are crucial for learning and remembering events. Considerable evidence indicates that the PFC and hippocampus become coupled via oscillatory synchrony that reflects bidirectional flow of information. Furthermore, newer studies have revealed specific mechanisms whereby neural representations in the PFC and hippocampus are mediated through direct connections or through intermediary regions. These findings suggest a model of how the hippocampus and PFC, along with their intermediaries, operate as a system that uses the current context of experience to retrieve relevant memories.

中文翻译：

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阵发性记忆中的前额叶-海马相互作用

海马和前额叶皮层（PFC）在记忆处理中的作用-单独或共同作用-是记忆研究中一个重要的主题。这些大脑区域在情节记忆中具有独特和互补的作用，它们的相互作用对于学习和记忆事件至关重要。大量证据表明，PFC和海马通过反映信息双向流动的振荡同步而耦合。此外，较新的研究已经揭示了通过直接连接或通过中间区域介导PFC和海马中神经表征的特定机制。这些发现为海马和PFC及其中介物如何作为一个使用当前经验背景来检索相关记忆的系统提供了模型。