One of the greatest global challenges is to feed the ever-increasing world population. The agrochemical tools growers currently utilize are also under continuous pressure, due to a number of factors that contribute to the loss of existing products. Mesoionic pyrido[1,2-a]pyrimidinones are an unusual yet very intriguing class of compounds. Known for several decades, this class of compounds had not been systemically studied until we started our insecticide discovery program. This Account provides an overview of the efforts on mesoionic pyrido[1,2-a]pyridinone insecticide discovery, beginning from the initial high throughput screen (HTS) discovery to ultimate identification of triflumezopyrim (4, DuPont Pyraxalt) and dicloromezotiaz (5) for commercialization as novel insecticides.

中文翻译：

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中离子吡啶并[1,2- a ]嘧啶酮类杀虫剂：从发现到三氟吡喃和双氯苯并噻唑

全球最大的挑战之一是养活不断增长的世界人口。由于造成现有产品损失的多种因素，种植者目前使用的农用化学工具也承受着持续的压力。中离子吡啶并[1,2- a ]嘧啶酮是一类不寻常但非常吸引人的化合物。在我们启动杀虫剂发现计划之前，几十年来一直没有对这类化合物进行过系统的研究。此帐户概述了从最初的高通量筛选（HTS）发现到最终鉴定三氟甲嘧啶（4，杜邦吡喃甲酰胺）和双氯唑并噻唑啉酮（5）以来对中离子吡啶并[1,2- a ]吡啶酮类杀虫剂的发现。）作为新型杀虫剂进行商业化。