There is a critical need for soft materials in the field of regenerative medicine and tissue engineering. However, designing injectable hydrogel scaffolds encompassing both adequate mechanical and biological properties remains a key challenge for in vivo applications. Here we use a bottom-up approach for synthesizing supramolecular gels to generate novel biomaterial candidates. We evaluated the low molecular weight gels candidates in vivo and identified one urea-containing molecule, compound 16, that avoid foreign body reactions in mice. The self-assembly of bolaamphiphiles creates a unique hydrogel supramolecular structures featuring fast gelation kinetics, high elastic moduli, thixotropic, and thermal reversibility properties. This soft material, which inhibits recognition by macrophages and fibrous deposition, exhibits long-term stability after in vivo injection.

中文翻译：

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低分子量水凝胶衍生自基于尿素的两亲物作为新型可注射生物材料

在再生医学和组织工程领域中迫切需要软材料。然而，设计涵盖足够的机械和生物学特性的可注射水凝胶支架仍然是体内应用的关键挑战。在这里，我们使用一种自下而上的方法来合成超分子凝胶，以生成新的生物材料候选物。我们评估了体内的低分子量凝胶候选物，并确定了一个含尿素的分子，即化合物16，可避免老鼠产生异物反应。保兰两亲分子的自组装产生了独特的水凝胶超分子结构，具有快速的凝胶动力学，高弹性模量，触变性和热可逆性。这种软材料抑制了巨噬细胞和纤维沉积的识别，在体内注射后显示出长期稳定性。