As a naturally molecular level organic-silica hybrid particle, polyhedral oligomeric silsesquioxane (POSS) has been proved to be a good choice for preparation of new hybrid monolithic columns with the merits of ease of fabrication, ultrahigh column efficiency and excellent separation selectivity. In this review, we summarize the recently reported POSS-based hybrid monolithic columns, especially those reported in the recent 5 years. These POSS-based hybrid monolithic columns are classified based on the reactive groups of POSSs as well as the introduced organically functionalized reagents, emphasizing the preparation methods and further applications in capillary liquid chromatography.

中文翻译：

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基于多面体低聚倍半硅氧烷的混合整体柱：毛细管液相色谱法的制备及其应用的最新进展

作为天然分子水平的有机硅杂化颗粒，多面体低聚倍半硅氧烷（POSS）具有易于制造，超高柱效和出色的分离选择性等优点，是制备新型杂化整体柱的理想选择。在这篇综述中，我们总结了最近报道的基于POSS的混合整体柱，尤其是最近5年中报道的那些。这些基于POSS的混合整体柱根据POSS的反应基团以及引入的有机功能化试剂进行分类，从而强调了制备方法和在毛细管液相色谱中的进一步应用。