A comprehensive analysis of small open reading frames (smORFs) in flies, mice and humans supports their classification into different functional groups, from inert DNA sequences to transcribed and translated smORFs that have various activities. The different smORF classes could represent steps in gene, peptide and protein evolution.

中文翻译：

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小型开放阅读框的分类和功能

对果蝇，小鼠和人类中的小开放阅读框（smORF）的全面分析支持将它们分类为不同的功能组，从惰性DNA序列到具有多种活性的转录和翻译的smORF。不同的smORF类可以代表基因，肽和蛋白质进化的步骤。