Theranostic nanomedicine, which uses both imaging and therapeutic components for simultaneous disease diagnosis and treatment, is expected to improve patient treatment safety and outcomes by offering a more personalized approach to medicine. However, the poor reproducibilities of nanomedicines synthesized for optimized bioavailability and their potential toxicity are impeding clinical development. Moreover, milligram-scale synthetic methods are often inconsistent when transferred to mass production. To address these challenges, a facile, room temperature, aqueous phase synthesis of nanotheranostic agents using clinically validated mesoporous silica and naturally derived polydopamine has been developed. Since the synthetic procedure is simple and robust, and requires only simple mixing under ambient conditions, excellent batch-to-batch consistency has been achieved. As a result, this process can be easily scaled-up to produce gram-scale batches with physicochemical parameters similar to those of materials synthesized in smaller batches. The resulting nanotheranostic agents exhibit efficient X-ray tomography and T1-weighted magnetic resonance image contrast enhancing abilities due to their chemically ligated, benign Bi³⁺ and Fe³⁺ ions. Furthermore, the inclusion of a polydopamine shell makes the nanoparticle surface easy to functionalize and renders these materials highly efficient as photothermal agents. These nanotheranostic agents are suitable for mass production and for potential applications in multimodal imaging-guided therapy in clinical settings.

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同时使用成像和治疗成分同时进行疾病诊断和治疗的Theranostic纳米医学有望通过提供更加个性化的医学方法来提高患者的治疗安全性和结果。然而，为优化生物利用度而合成的纳米药物的低再现性及其潜在的毒性阻碍了临床发展。此外，毫克级合成方法在转入批量生产时通常不一致。为了应对这些挑战，已经开发了使用临床上经验证的介孔二氧化硅和天然衍生的聚多巴胺，在室温下容易地合成纳米热敏剂的技术。由于合成过程简单而稳定，并且仅需在环境条件下进行简单混合即可，实现了极好的批次间一致性。结果，该方法可以容易地按比例放大以生产具有类似于小批量合成的材料的物理化学参数的克级批量。由于其化学连接的良性Bi，所得的纳米热剂显示出有效的X射线断层扫描和T1加权磁共振图像对比增强能力。³⁺和Fe ³⁺离子。此外，包含聚多巴胺壳使得纳米颗粒表面易于功能化，并使这些材料作为光热剂非常有效。这些纳米治疗剂适用于大规模生产，并适合在临床环境中在多峰成像引导疗法中应用。

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