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N-Arylation of Heterocycles by a Tandem Aza-Michael Addition Reaction and Aromatization Sequence
Synlett ( IF 1.7 ) Pub Date : 2017-08-17 , DOI: 10.1055/s-0036-1588538
Santhosh Chittimalla , Srinuvasu Nakka , Manikandan Koodalingam , Chennakesavulu Bandi

Cyclohexa-2,4-dien-1-one derivatives, upon reaction with N-heterocycles in the presence of scandium(III) triflate, underwent a tandem Michael addition reaction followed by aromatization of the ­Michael adduct generated in situ to give N-aryl heterocycles in good yields. Because of the ready accessibility of variously substituted cyclohexa-2,4-dien-1-ones, a range of N-aryl heterocycles have become available.

中文翻译:

通过串联氮杂-迈克尔加成反应和芳构化序列对杂环进行 N-芳基化

Cyclohexa-2,4-dien-1-one 衍生物在三氟甲磺酸钪 (III) 存在下与 N-杂环反应后,进行串联迈克尔加成反应,然后原位生成的迈克尔加合物芳构化得到 N-芳基杂环的收率很好。由于各种取代的 cyclohexa-2,4-dien-1-ones 很容易获得,一系列 N-芳基杂环已经变得可用。
更新日期:2017-08-17
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