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Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines
Synlett ( IF 1.7 ) Pub Date : 2017-08-17 , DOI: 10.1055/s-0036-1588533
Chenghui Sun , Honggang Liang , Lingxiang Bao , Yao Du , Yiying Zhang , Siping Pang

Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyan­amides through an N-deallylation reaction and an N-cyanation reaction in one pot.

中文翻译:

通过烯丙基叔胺的 N-氰化在温和条件下由溴化氰合成氰胺

通过烯丙基叔胺与溴化氰的一步亲核取代反应选择性地形成氰胺。由于反应条件温和,反应收率良好,以及起始原料的商业可用性,这种新方法代表了通过 N-脱烯丙基化反应和 N-氰化反应合成氰胺的一种有价值的工具。锅。
更新日期:2017-08-17
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