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Principles of Chemical Biology: Iron and CSCs, Histone Acylation sans Enzymes, Eliciting Silent Gene Clusters, and 2′-deoxy-ADPR as a Second Messenger
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2017-08-17 , DOI: 10.1016/j.chembiol.2017.07.016


This month: Lysosomal iron linked to cell death in cancer stem cells, non-enzymatic catalyst SynCAc for histone acylation, cytotoxins ivermectin and etoposide bring new anti-fungals out of the crypt, and 2′-deoxy-ADPR as second messenger activating TRPM2.

中文翻译:

化学生物学原理:铁和CSC,无酶的组蛋白酰化,消除沉默基因簇,以及2'-deoxy-ADPR作为第二信使

本月:与癌症干细胞死亡相关的溶酶体铁,用于组蛋白酰化的非酶催化剂SynCAc,细胞毒素伊维菌素和依托泊苷将新的抗真菌剂带出了隐窝,而2'-deoxy-ADPR作为激活TRPM2的第二信使。
更新日期:2017-08-17
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