In order to develop a streptavidin-biotin system with optimal performance in fluorescent labeling, in this issue ofCell Chemical Biology,Jacobsen et al. (2017)focused on changing the surface density of amino groups present on streptavidin via lysine mutagenesis. The streptavidin mutant containing only one free amino group was found superior to other streptavidin variants and was named Flavidin for fluorophore-friendly streptavidin.

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优化的链霉亲和素用于生物素化靶标的荧光标记

为了开发在荧光标记中具有最佳性能的抗生蛋白链菌素-生物素系统，在本期《细胞化学生物学》杂志上，Jacobsen等人。（2017）专注于通过赖氨酸诱变改变链霉亲和素上存在的氨基的表面密度。发现仅包含一个游离氨基的链霉亲和素突变体优于其他链霉亲和素变体，并且由于对荧光团友好的链霉亲和素而被命名为黄素蛋白。