Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories.,Cell

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Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories.
Cell ( IF 45.5 ) Pub Date : 2017-Aug-24 , DOI: 10.1016/j.cell.2017.07.013
Dheeraj S Roy ₁ , Takashi Kitamura ₁ , Teruhiro Okuyama ₁ , Sachie K Ogawa ₁ , Chen Sun ₁ , Yuichi Obata ₂ , Atsushi Yoshiki ₂ , Susumu Tonegawa ₃

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The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells) by a common set of neural circuits, but this hypothesis has not been established. The medial temporal-lobe system is essential for the formation and retrieval of episodic memory for which individual hippocampal subfields and entorhinal cortex layers contribute by carrying out specific functions. One subfield whose function is poorly known is the subiculum. Here, we show that dorsal subiculum and the circuit, CA1 to dorsal subiculum to medial entorhinal cortex layer 5, play a crucial role selectively in the retrieval of episodic memories. Conversely, the direct CA1 to medial entorhinal cortex layer 5 circuit is essential specifically for memory formation. Our data suggest that the subiculum-containing detour loop is dedicated to meet the requirements associated with recall such as rapid memory updating and retrieval-driven instinctive fear responses.

中文翻译：

情景记忆形成和检索的不同神经回路。

记忆的形成和恢复被认为是通过一组共同的神经回路分别激活和重新激活记忆保持细胞（印迹细胞）来完成的，但这一假设尚未成立。内侧颞叶系统对于情景记忆的形成和检索至关重要，海马体亚区和内嗅皮质层通过执行特定功能对此做出贡献。一个功能鲜为人知的子域是下托。在这里，我们表明背下托和电路，CA1 到背下托到内侧内嗅皮层第 5 层，选择性地在情景记忆的检索中起着至关重要的作用。相反，直接 CA1 到内侧内嗅皮层第 5 层电路对于记忆形成特别重要。

更新日期：2017-08-17

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